Scientist (Screening and Target Discovery)

Summary:

PhoreMost® are looking for talented and innovative scientists to join our functional genomic screening team and support our revolutionary discovery campaigns. We have developed a next-generation, high-throughput screening platform called SITESEEKER® to identify the best new targets for future therapy and the mechanisms to drug them. Our technology is positioned to massively expand the diversity of novel 

Who we are: 

We are an integrated drug discovery company located in Cambridge, UK. We have developed a next-generation, high-throughput discovery screening platform called SITESEEKER® to identify the best new targets for future therapy and the mechanisms to drug them. By integrating AI-based analysis and neural network learning approaches, we are coupling novel and rich biological discovery data to high dimensional computational approaches. PhoreMost has developed a number of partnerships and an exciting pipeline of first-in-class drug discovery programmes spanning multiple therapeutic areas including oncology, immuno-oncology and ageing. We have a growing franchise in induced proximity control, including targeted protein degradation, which we are leveraging to develop new therapeutic products. Our technology is massively expanding the diversity of novel therapeutics for several key diseases of unmet clinical need – we are drugging the undruggable®. 

Roles and responsibilities: 

• Plan and perform pooled functional genomic SITESEEKER® screens for internal or collaboration projects 
• Develop and validate novel assays and technologies suitable for screening 
• Assist in the project management of screening programmes to ensure that technical, scientific and reporting milestones are met 
• Obtain or define new cell models and perform rigorous assay development experiments to establish optimal screening conditions 
• Design and execute target validation analyses to confirm hits identified from these screens in secondary assays and progress them towards drug discovery 

Requirements: 

• PhD or equivalent research experience 
• Outstanding molecular biology expertise including in cloning and PCR 
• Outstanding technical aptitude in mammalian cell tissue culture 
• Good team player, enthusiastic, exceptionally driven and actively seeking to learn and develop 
• Demonstrated capability for successfully and independently balancing the requirements of multiple projects at any given time 
• Attention to detail, structured thinking, consistent and reliable, excellent communication 
• Committed to the pursuit of new therapies for critical unmet clinical need 

Desired additional qualifications (but not required): 

• Experience in pooled functional genomic screening (e.g. shRNA, CRISPR, GeneTrap) 
• Proficiency with lentivirus or retrovirus tools work and flow cytometry expertise 
• Demonstrated experience in the field of proteostasis or targeted protein degradation 
• A good understanding of statistics and data handling skills (e.g. R, KNIME etc) 

Time: This is a permanent full-time, laboratory-based position. 

Benefits: Equity Participation, Private Health, competitive salary, life assurance and more. 

You must be eligible to work in the UK to apply for this role