Cell-Based Assay Scientist

PhoreMost

Role Description 

PhoreMost® are looking for a talented and innovative cellular pharmacologist with drug discovery experience to join our Target Biology team. The position can be appointed at Scientist or Senior Scientist level dependent upon experience. The successful candidate will play a key role in helping to validate novel targets and to understand the mechanism of hits arising from our target discovery SITESEEKER® platform. Primary responsibilities will include providing cell biology support to PhoreMost’s drug discovery campaigns and the development of disease-relevant cellular models for use in project specific assays. This is a laboratory-based position within a dynamic and multi-disciplinary organisation. 

About Us 

We are a biotech company located in Cambridge, UK. We have developed a next-generation high-throughput screening platform called SITESEEKER® to identify the best new targets for future therapy and the mechanisms to drug them. Our SITESEEKER® platform uses a cutting-edge approach called PROTEINi® (protein interference) to identify novel targets. This technology has the ability to identify hidden or cryptic drug sites in disease-relevant proteins that might be missed using conventional methods of target discovery. PhoreMost has developed a number of partnerships and an exciting pipeline of first-in-class drug discovery programmes spanning multiple therapeutic areas including oncology, immuno-oncology, and ageing. Our technology is positioned to massively expand the diversity of novel therapeutics for several key diseases of unmet clinical need – we are drugging the undruggable. 

PhoreMost® is proud to be an equal opportunities employer. We are committed to creating an inclusive working environment and we celebrate diversity. Every application will be evaluated based on merit and without discrimination. 

Roles and Responsibilities 

  • Contribute to drug discovery project progression through development of cell-based assay systems that support target validation, biomarker and mechanistic studies
  • Generate scientific ideas and implement in disease-relevant cell culture models across a range of therapeutic areas
  • Design and perform experiments to validate novel targets utilising tool compounds and genetic knockdown/editing approaches
  • Conduct compound profiling to support Drug Discovery efforts
  • Analyse and interpret experimental results to ensure maximum impact to project strategy and decision-making
  • Work collaboratively within the multi-disciplinary Target Biology, Drug Discovery and Target Discovery teams (also potentially including external collaborators)
  • Maintain an up-to-date and accurate electronic laboratory notebook 
  • Communicate effectively and present results to diverse audiences including to internal teams and external partners
  • Additional Senior Scientist responsibilities may include leading early-stage projects (depending on experience) 

Person Specification 

Essential

  • PhD or equivalent experience in a relevant life science discipline
  • Industry experience or equivalent experience in a translationally focused setting
  • Experience developing assays to assess phenotypic endpoints and/or pathway modulation
  • Drug discovery/ cellular pharmacology experience working with novel chemical matter
  • Excellent working experience of mammalian cell culture
  • Knowledge of and experience in cell and molecular biology techniques (e.g. western blotting, RT-PCR, imaging, ELISA and other plate-based assays)
  • Excellent team player, enthusiastic and actively seeking to learn and develop
  • Attention to detail, structured thinking, good communication and time management skills
  • Committed to the pursuit of new therapies for critical unmet clinical need 

Desired

  • Experience with techniques commonly used for target validation studies including siRNA, shRNA, CRISPR, tool compounds (essential for Senior Scientist appointment) 

Benefits: Equity Participation, Bench-marked Salaries, Life Assurance, Discretionary Bonus, Private health and others 

You must be eligible to work in the UK to apply for this role 

 

JLL
Paddy Shipp | 07469 155 531
paddy.shipp@eu.jil.com
www.jll.co.uk

Savills
William Clarke | 01223 347 294
wclarke@savills.com
www.savills.co.uk

Howard Group
-